Personalised Cancer Medicine Flashcards 2022
Indications determined by the organ of origin
Gastric Cancer
Standard
Recommended
Currently not recommended
- HER2
- Microsatellite Instability*
- PDL-1
- VEGFR
- EGFR
- MET
- EBV
* By either IHQ (MLH1, PMS2, MSH2 and MSH6) or by Genomic studies (BAT25 and BAT26, D2S123, D5S346 and D17S250).
The Standard category is based on current treatment indications with approved funding by the Spanish National Health System.
The Recommended category is based on currentrecommendations by EMEA and FDA.
The Recommended category is based on currentrecommendations by EMEA and FDA.
References:
1. Gómez-Martín C, Concha A, Corominas JM, et al; Spanish Society of Medical Oncology; Spanish Society of Pathology. Consensus of the Spanish Society of Medical Oncology (SEOM) and Spanish Society of Pathology (SEAP) for HER2 testing in gastric carcinoma. Clin Transl Oncol. 2011 Sep;13(9):636-51. doi: 10.1007/s12094-011-0709-7.
2. Shitara K, Van Cutsem E, Bang YJ, et al. Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial. JAMA Oncol. 2020 Oct 1;6(10):1571-1580. doi: 10.1001/jamaoncol.2020.3370.
