Personalised Cancer Medicine Flashcards 2022
Standard
Recommended
Currently not recommended
- BRCA1 and BRCA2*
- Microsatellite instability*
- HRR Profound panel* (somatic)
- Androgen receptor aberrations
- PDL1
- PTEN
The Recommended category is based on currentrecommendations by EMEA and FDA.
References:
1. de Bono J, Mateo J, Fizazi K, et al. Olaparib for Metastatic Castration-Resistant Prostate Cancer. N Engl J Med. 2020 May 28;382(22):2091-2102. doi: 10.1056/NEJMoa1911440.
2. To SQ, Kwan EM, Fettke HC, et al. Expression of Androgen Receptor Splice Variant 7 or 9 in Whole Blood Does Not Predict Response to Androgen-Axis-targeting Agents in Metastatic Castration-resistant Prostate Cancer. Eur Urol. 2018 Jun;73(6):818-821. doi: 10.1016/j.eururo.2018.01.007.
3. Beltran H, Antonarakis ES, Morris MJ, Attard G. Emerging Molecular Biomarkers in Advanced Prostate Cancer: Translation to the Clinic. Am Soc Clin Oncol Educ Book. 2016;35:131-41. doi: 10.1200/EDBK_159248.