Personalised Cancer Medicine Flashcards 2025

Indications determined by the organ of origin
Melanoma
Melanoma

Standard

Recommended

Currently not recommended
  • BRAF
  • KIT*
  • NRAS
  • GNAQ/GNA11
  • PTEN
  • MITF
  • CDKN2A
  • MHC-II
  • Tumor mutational burden
* in mucosal or acral melanoma or melanoma associated with sunlight
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The Standard category is based on current treatment indications with approved funding by the Spanish National Health System.
The Recommended category is based on currentrecommendations by EMEA and FDA.

References:

1. Amaral T, Ottaviano M, Arance A, et al; ESMO Guidelines Committee. Cutaneous melanoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2025 Jan;36(1):10-30. doi: 10.1016/j.annonc.2024.11.006.

2. European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics Update 2024. Garbe, Claus et al. European Journal of Cancer, Volume 215, 115152.

3. Márquez-Rodas I, Muñoz Couselo E, Rodríguez Moreno JF, Arance Fernández AM, Berciano Guerrero MÁ, Campos Balea B, de la Cruz Merino L, Espinosa Arranz E, García Castaño A, Berrocal Jaime A. SEOM-GEM clinical guidelines for cutaneous melanoma (2023). Clin Transl Oncol. 2024 Nov;26(11):2841-2855. doi: 10.1007/s12094-024-03497-2. Epub 2024 May 15. PMID: 38748192; PMCID: PMC11467041.